Article
The metabolic perturbators metformin, phenformin and AICAR interfere with the growth and survival of murine PTEN-deficient T cell lymphomas and human T-ALL/T-LL cancer cells.
Cancer letters - 9 Aug 2013
Rosilio Célia, Lounnas Nadia, Nebout Marielle, Imbert Véronique, Hagenbeek Thijs, Spits Hergen, Asnafi Vahid, Pontier-Bres Rodolphe, Reverso Julie, Michiels Jean-François, Sahra Issam Ben, Bost Fréderic, Peyron Jean-François
Abstract excerpt
We show here that the antidiabetic agents metformin and phenformin and the AMPK activator AICAR exert strong anti-tumoural effects on tPTEN-/- lymphoma cells and on human T-ALL cell lines and primary samples. The compounds act by inhibiting tumour metabolism and proliferation and by inducing apoptosis in parallel with an activation of AMPK and an inhibition of constitutive mTOR. In tPTEN-/- cells, the drugs...
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