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Article

The role of Arg445 and Asp498 in the human thyroid hormone transporter MCT8.

Endocrinology - 1 Feb 2014

Groeneweg Stefan, Friesema Edith C H, Kersseboom Simone, Klootwijk Wim, Visser W Edward, Peeters Robin P, Visser Theo J

Abstract excerpt

Monocarboxylate transporter 8 (MCT8) facilitates cellular influx and efflux of the thyroid hormones (THs) T(4) and T(3). Mutations in MCT8 lead to severe psychomotor retardation. Here, we studied the importance of 2 highly conserved residues (Arg445 in transmembrane domain 8 and Asp498 in transmembrane domain 10) for substrate recognition and helix interactions. We introduced single and double mutations (R445A,...

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Identifiers

PMID: 24265446
DOI: 10.1210/en.2013-1521

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