Article
High phospho-Stathmin(Serine38) expression identifies aggressive endometrial cancer and suggests an association with PI3K inhibition.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2013
Wik Elisabeth, Birkeland Even, Trovik Jone, Werner Henrica M J, Hoivik Erling A, Mjos Siv, Krakstad Camilla, Kusonmano Kanthida, Mauland Karen, Stefansson Ingunn M, Holst Frederik, Petersen Kjell, Oyan Anne M, Simon Ronald, Kalland Karl H, Ricketts William, Akslen Lars A, Salvesen Helga B
Abstract excerpt
PURPOSE: High Stathmin expression has recently been associated with clinical progress in endometrial cancers. Stathmin protein activity is modulated by phosphorylation, and the Serine38 site is one of four Stathmin phospho-sites. The presence and significance of pStathmin(S38) is largely unknown in human cancers, and we here examined the associations between this marker and tumor cell proliferation,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
