Article
Effect of stathmin on the sensitivity to antimicrotubule drugs in human breast cancer.
Cancer research - 1 Dec 2002
Alli Elizabeth, Bash-Babula Judy, Yang Jin-Ming, Hait William N
Abstract excerpt
Stathmin is a p53-regulated protein known to influence microtubule dynamics. Because several chemotherapeutic agents used to treat breast cancer alter the dynamic equilibrium of tubulin polymerization, stathmin may play an important role in determining the sensitivity to these drugs. Therefore, we evaluated the effect of stathmin expression on the action of taxanes and Vinca alkaloids using a panel of human...
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