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Article

Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation.

Proceedings of the National Academy of Sciences of the United States of America - 7 May 2013

Gerlic Motti, Faustin Benjamin, Postigo Antonio, Yu Eric Chi-Wang, Proell Martina, Gombosuren Naran, Krajewska Maryla, Flynn Rachel, Croft Michael, Way Michael, Satterthwait Arnold, Liddington Robert C, Salek-Ardakani Shahram, Matsuzawa Shu-ichi, Reed John C

Abstract excerpt

Host innate immune responses to DNA viruses involve members of the nucleotide-binding domain, leucine-rich repeat and pyrin domain containing protein (NLRP) family, which form "inflammasomes" that activate caspase-1, resulting in proteolytic activation of cytokines interleukin (IL)-1β and IL-18. We hypothesized that DNA viruses would target inflammasomes to overcome host defense. A Vaccinia virus (VACV) B-cell...

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Source

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Identifiers

PMID: 23603272
DOI: 10.1073/pnas.1215995110
PMCID: PMC3651467

Genes

NLRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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