Article
Inhibition of apoptosis and NF-κB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence.
PLoS pathogens - 1 Dec 2011
Maluquer de Motes Carlos, Cooray Samantha, Ren Hongwei, Almeida Gabriel M F, McGourty Kieran, Bahar Mohammad W, Stuart David I, Grimes Jonathan M, Graham Stephen C, Smith Geoffrey L
Abstract excerpt
Vaccinia virus (VACV) protein N1 is an intracellular virulence factor and belongs to a family of VACV B-cell lymphoma (Bcl)-2-like proteins whose members inhibit apoptosis or activation of pro-inflammatory transcription factors, such as interferon (IFN) regulatory factor-3 (IRF-3) and nuclear factor-κB (NF-κB). Unusually, N1 inhibits both apoptosis and NF-κB activation. To understand how N1 exerts these different...
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