Article

ErbB Signalling is a Potential Therapeutic Target for Vascular Lesions with Fibrous Component

2022-09-25

Abstract excerpt

<h4>Background: </h4> Sporadic venous malformation (VM) and angiomatosis of soft tissue (AST) are benign, congenital vascular anomalies affecting venous vasculature. Depending on the size and location of the lesion, symptoms vary from motility disturbances to pain and disfigurement. Due to high recurrence of the lesions more effective therapies are needed. <h4>Methods:</h4> As targeting stromal cells has been an e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 06b43b14-a8ab-5dbb-a4be-947858416213
DOI: 10.1101/2022.09.23.509204

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ErbB Signalling is a Potential Therapeutic Target for Vascular Lesions with Fibrous ComponentDOI 10.1101/2022.09.23.509204Read

Emerging importance of molecular pathogenesis of vascular malformations in clinical practice and classifications.Semantic proximity Read

Genetic Causes of Vascular Malformations and Common Signaling Pathways Involved in Their Formation.Semantic proximity Read

Molecular landscape and classification of vascular anomalies.Semantic proximity Read

Vascular malformations: An overview of their molecular pathways, detection of mutational profiles and subsequent targets for drug therapySemantic proximity Read

Angiopoietin–TIE2 feedforward circuit promotes PIK3CA-driven venous malformationsSemantic proximity Read

Genetic Basis and Therapies for Vascular Anomalies.Semantic proximity Read

AKT/FOXO1 axis links cross-talking of endothelial cell and pericyte in TIE2-mutated venous malformationsSemantic proximity Read

AKT/FOXO1 axis links cross-talking of endothelial cell and pericyte in TIE2-mutated venous malformationsSemantic proximity Read

Phenotypic Transition of Vascular Smooth Muscle Cells Induced by Endothelial TIE2 Mutations in Venous MalformationsSemantic proximity Read

Development of Molecular Therapies for Venous Malformations.Semantic proximity Read

Targeted Therapies for Slow‐Flow Vascular MalformationsSemantic proximity Read

The genetics of vascular tumours: an update.Semantic proximity Read