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Article

The colchicine derivative CT20126 shows a novel microtubule-modulating activity with apoptosis

19 Apr 2013

Abstract excerpt

New colchicine analogs have been synthesized with the aim of developing stronger potential anticancer activities. Among the analogs, CT20126 has been previously reported to show immunosuppressive activities. Here, we report that CT20126 also shows potential anticancer effects via an unusual mechanism: the modulation of microtubule integrity and cell cycle arrest at the G2/M phase before apoptosis. When we treated...

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PMID: 23598593
DOI: 10.1038/emm.2013.38

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