Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regional modulation of a stochastically expressed factor determines photoreceptor subtypes in the Drosophila retina.

Developmental cell - 15 Apr 2013

Thanawala Shivani U, Rister Jens, Goldberg Gregory W, Zuskov Andrey, Olesnicky Eugenia C, Flowers Jonathan M, Jukam David, Purugganan Michael D, Gavis Elizabeth R, Desplan Claude, Johnston Robert J

Abstract excerpt

Stochastic mechanisms are sometimes utilized to diversify cell fates, especially in nervous systems. In the Drosophila retina, stochastic expression of the PAS-bHLH transcription factor Spineless (Ss) controls photoreceptor subtype choice. In one randomly distributed subset of R7 photoreceptors, Ss activates Rhodopsin4 (Rh4) and represses Rhodopsin3 (Rh3); counterparts lacking Ss express Rh3 and repress Rh4. In...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryl Hydrocarbon Receptor Nuclear Translocator
Share to Embryo, Nonmammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Green Fluorescent Proteins

Share to Photoreceptor Cells, Vertebrate

Share to Protein Multimerization

Share to Receptors, Aryl Hydrocarbon

Share to Retina

Share to Rhodopsin

Source

Open in PubMed Open full text

Identifiers

PMID: 23597484
DOI: 10.1016/j.devcel.2013.02.016
PMCID: PMC3660048

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regional modulation of a stochastically expressed factor determines photoreceptor subtypes in the Drosophila retina.PMID 23597484Read ↗

Interchromosomal communication coordinates intrinsically stochastic expression between alleles.Semantic proximity Read ↗

Stochastic spineless expression creates the retinal mosaic for colour vision.Semantic proximity Read ↗

Transcriptional priming and chromatin regulation during stochastic cell fate specification.Semantic proximity Read ↗

Loss of seven-up from Drosophila R1/R6 photoreceptors reveals a stochastic fate choice that is normally biased by Notch.Semantic proximity Read ↗

Two-step selection of a single R8 photoreceptor: a bistable loop between senseless and rough locks in R8 fate.Semantic proximity Read ↗

Single-base pair differences in a shared motif determine differential Rhodopsin expression.Semantic proximity Read ↗

Stochastic yet biased expression of multiple Dscam splice variants by individual cells.Semantic proximity Read ↗

Patterning of the R7 and R8 photoreceptor cells of Drosophila: evidence for induced and default cell-fate specification.Semantic proximity Read ↗

senseless repression of rough is required for R8 photoreceptor differentiation in the developing Drosophila eye.Semantic proximity Read ↗

Design principles and developmental mechanisms underlying retinal mosaics.Semantic proximity Read ↗

A temporal mechanism that produces neuronal diversity in the Drosophila visual center.Semantic proximity Read ↗

Coordinate control of synaptic-layer specificity and rhodopsins in photoreceptor neurons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.