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Article

Attenuated and replication-competent vaccinia virus strains M65 and M101 with distinct biology and immunogenicity as potential vaccine candidates against pathogens.

Journal of virology - 1 Jun 2013

Sánchez-Sampedro Lucas, Gómez Carmen Elena, Mejías-Pérez Ernesto, Pérez-Jiménez Eva, Oliveros Juan Carlos, Esteban Mariano

Abstract excerpt

Replication-competent poxvirus vectors with an attenuation phenotype and with a high immunogenic capacity of the foreign expressed antigen are being pursued as novel vaccine vectors against different pathogens. In this investigation, we have examined the replication and immunogenic characteristics of two vaccinia virus (VACV) mutants, M65 and M101. These mutants were generated after 65 and 101 serial passages of...

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Identifiers

PMID: 23596295
DOI: 10.1128/JVI.03013-12
PMCID: PMC3676094

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