Article
Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: scarification vaccination.
Vaccine - 2 Jun 2008
Jentarra Garilyn M, Heck Michael C, Youn Jin Won, Kibler Karen, Langland Jeffrey O, Baskin Carole R, Ananieva Olga, Chang Yung, Jacobs Bertram L
Abstract excerpt
In this study, we evaluated the efficacy of vaccinia virus (VACV) containing mutations in the E3L virulence gene to protect mice against a lethal poxvirus challenge after vaccination by scarification. VACV strains with mutations in the E3L gene had significantly decreased pathogenicity, even in immune deficient mice, yet retained the ability to produce a potent Th1-dominated immune response in mice after...
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