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Article

Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: scarification vaccination.

Vaccine - 2 Jun 2008

Jentarra Garilyn M, Heck Michael C, Youn Jin Won, Kibler Karen, Langland Jeffrey O, Baskin Carole R, Ananieva Olga, Chang Yung, Jacobs Bertram L

Abstract excerpt

In this study, we evaluated the efficacy of vaccinia virus (VACV) containing mutations in the E3L virulence gene to protect mice against a lethal poxvirus challenge after vaccination by scarification. VACV strains with mutations in the E3L gene had significantly decreased pathogenicity, even in i...

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Identifiers

PMID: 18455281
DOI: 10.1016/j.vaccine.2008.03.044
PMCID: PMC2488381

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18455281-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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