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Article

Conditionally activated E7 proteins of high-risk and low-risk human papillomaviruses induce S phase in postmitotic, differentiated human keratinocytes.

Journal of virology - 1 Jul 2006

Banerjee N Sanjib, Genovese Nicholas J, Noya Francisco, Chien Wei-Ming, Broker Thomas R, Chow Louise T

Abstract excerpt

The productive program of human papillomaviruses (HPVs) in epithelia is tightly linked to squamous differentiation. The E7 proteins of high-risk HPV genotypes efficiently inactivate the pRB family of proteins that control the cell cycle, triggering S phase in suprabasal keratinocytes. This ability has until now not been demonstrated for the low-risk HPV-6 or HPV-11 E7 proteins. An inducible system in which HPV-16...

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Source

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Identifiers

PMID: 16775338
DOI: 10.1128/JVI.02499-05
PMCID: PMC1488939

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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