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Article

Up-regulation of Smurf1 after spinal cord injury in adult rats.

Journal of molecular histology - 1 Aug 2013

Li Debao, Zhang Jinlong, Huang Wei, Jin Huricha, Shen Aiguo, Yang Longfei, Liu Jian, Fan Jianbo, Zhou Qingzhong, Wen Hai, Hu Yong, Cui Zhiming

Abstract excerpt

Smad ubiquitination regulatory factor 1 (Smurf1) is one of members of the Hect family of proteins, which also includes the ubiquitin E3-type ligases Nedd3 and E6-AP. As an E3 ligase, Smurf1 selectively interacts with receptor-regulated Smads to trigger their ubiquitination and degradation. Recently, a report indicates that Smurf1 can inhibit apoptosis by regulating p53 negatively, which depends on the effect of...

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Identifiers

PMID: 23595775
DOI: 10.1007/s10735-013-9499-2

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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