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Article

CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors

24 Aug 2017

Abstract excerpt

Effective targeting of cancer stem cells (CSCs) requires neutralization of self-renewal and chemoresistance, but these phenotypes are often regulated by distinct molecular mechanisms. Here we report the ability to target both of these phenotypes via CD55, an intrinsic cell surface complement inhibitor, which was identified in a comparative analysis between CSCs and non-CSCs in endometrioid cancer models. In this...

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PMID: 28838952
DOI: 10.1084/jem.20170438

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