Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bone marrow transplantation stimulates neural repair in Friedreich's ataxia mice.

Annals of neurology - 1 Apr 2018

Kemp Kevin C, Hares Kelly, Redondo Juliana, Cook Amelia J, Haynes Harry R, Burton Bronwen R, Pook Mark A, Rice Claire M, Scolding Neil J, Wilkins Alastair

Abstract excerpt

OBJECTIVE: Friedreich's ataxia is an incurable inherited neurological disease caused by frataxin deficiency. Here, we report the neuroreparative effects of myeloablative allogeneic bone marrow transplantation in a humanized murine model of the disease. METHODS: Mice received a transplant of fluorescently tagged sex-mismatched bone marrow cells expressing wild-type frataxin and were assessed at monthly intervals...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Transplantation
Share to Exploratory Behavior

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Frataxin

Share to Friedreich Ataxia

Share to Ganglia, Spinal

Share to Granulocyte Colony-Stimulating Factor

Share to Iron-Binding Proteins

Share to Muscle Strength

Source

Open in PubMed Open full text

Identifiers

PMID: 29534309
DOI: 10.1002/ana.25207
PMCID: PMC5947591

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bone marrow transplantation stimulates neural repair in Friedreich's ataxia mice.PMID 29534309Read ↗

Interferon gamma upregulates frataxin and corrects the functional deficits in a Friedreich ataxia modelSemantic proximity Read ↗

Advances in Gene and Cellular Therapy in Friedreich Ataxia.Semantic proximity Read ↗

Stem cell transplantation for neurodegenerative diseases.Semantic proximity Read ↗

A multiple animal and cellular models approach to study frataxin deficiency in Friedreich Ataxia.Semantic proximity Read ↗

Myelosuppressive conditioning using busulfan enables bone marrow cell accumulation in the spinal cord of a mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Excision of Expanded GAA Repeats Alleviates the Molecular Phenotype of Friedreich's Ataxia.Semantic proximity Read ↗

Cerebellar Allografts Survive and Transiently Alleviate Ataxia in a Transgenic Model of Spinocerebellar Ataxia Type-1Semantic proximity Read ↗

CNS repair and axon regeneration: Using genetic variation to determine mechanisms.Semantic proximity Read ↗

Transplanted Modified Muscle Progenitor Cells Expressing a Mixture of Neurotrophic Factors Delay Disease Onset and Enhance Survival in the SOD1 Mouse Model of ALSSemantic proximity Read ↗

Central Nervous System-directed AAV2/5-Mediated Gene Therapy Synergizes with Bone Marrow Transplantation in the Murine Model of Globoid-cell LeukodystrophySemantic proximity Read ↗

Functional recovery in a Friedreich's ataxia mouse model by frataxin gene transfer using an HSV-1 amplicon vector.Semantic proximity Read ↗

Stable fusion of bone marrow-derived cells with Purkinje neurons enables long-term nuclear integration and neuronal repairSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.