Article
An integrative approach for identifying a metabolic phenotype predictive of individualized pharmacokinetics of tacrolimus.
Clinical pharmacology and therapeutics - 1 Apr 2010
Phapale P B, Kim S-D, Lee H W, Lim M, Kale D D, Kim Y-L, Cho J-H, Hwang D, Yoon Y-R
Abstract excerpt
Individual variation in drug response is influenced by both genes and environment. We evaluated the potential of a metabolic phenotype to predict individual variation in the pharmacokinetics (PK) of tacrolimus. Liquid chromatography-mass spectroscopy (LC-MS)-based metabolic profiling was performed on 29 healthy volunteers by measuring the levels of 1,256 metabolite ions in their predose urine samples. After oral...
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