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Article

Targeted Delivery of Doxorubicin to Mitochondria

16 Apr 2013

Abstract excerpt

Several families of highly effective anticancer drugs are selectively toxic to cancer cells because they disrupt nucleic acid synthesis in the nucleus. Much less is known, however, about whether interfering with nucleic acid synthesis in the mitochondria would have significant cellular effects. In this study, we explore this with a mitochondrially targeted form of the anticancer drug doxorubicin, which inhibits...

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PMID: 23590228
DOI: 10.1021/cb400095v

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