Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial delivery of doxorubicin via triphenylphosphine modification for overcoming drug resistance in MDA-MB-435/DOX cells.

Molecular pharmaceutics - 4 Aug 2014

Han Min, Vakili Mohammad Reza, Soleymani Abyaneh Hoda, Molavi Ommoleila, Lai Raymond, Lavasanifar Afsaneh

Abstract excerpt

In this study, doxorubicin (DOX) was conjugated to a lipophilic triphenylphosphonium (TPP) that is selectively taken up by the mitochondrial membrane of cells. This new derivative of DOX, i.e., TPP-DOX, was characterized by infrared spectroscopy (IR), nuclear magnetic resonance ((1)H NMR, (13)C N...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotics, Antineoplastic
Share to Doxorubicin
Share to Drug Design

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inhibitory Concentration 50

Share to Magnetic Resonance Spectroscopy

Share to Organophosphorus Compounds

Share to Spectrophotometry, Infrared

Share to Spectroscopy, Fourier Transform Infrared

Source

Identifiers

PMID: 24811541
DOI: 10.1021/mp500038g

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24811541-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial delivery of doxorubicin via triphenylphosphine modification for overcoming drug resistance in MDA-MB-435/DOX cells.PMID 24811541Read ↗

Targeting DRP1 mediated mitochondrial metabolism as a novel treatment strategy for triple negative breast cancer (TNBC)Semantic proximity Read ↗

Mitochondrial transplantation regulates antitumour activity, chemoresistance and mitochondrial dynamics in breast cancerSemantic proximity Read ↗

Targeted Delivery of Doxorubicin to MitochondriaSemantic proximity Read ↗

Chemical strategies for delivery of compounds to mitochondriaSemantic proximity Read ↗

A PI polyamide-TPP conjugate targeting a mtDNA mutation induces cell death of cancer cells with the mutation.Semantic proximity Read ↗

Intelligent TAT-coupled anti-HER2 immunoliposomes knock downed MDR1 to produce chemosensitize phenotype of multidrug resistant carcinoma.Semantic proximity Read ↗

Microparticle drug sequestration provides a parallel pathway in the acquisition of cancer drug resistance.Semantic proximity Read ↗

Relationship between therapeutic efficacy of doxorubicin-transferrin conjugate and expression of P-glycoprotein in chronic erythromyeloblastoid leukemia cells sensitive and resistant to doxorubicinSemantic proximity Read ↗

A platinum-based hybrid drug design approach to circumvent acquired resistance to molecular targeted tyrosine kinase inhibitors.Semantic proximity Read ↗

Polymeric Encapsulation of a Ruthenium Polypyridine Complex for Tumor Targeted 1- and 2-Photon Photodynamic TherapySemantic proximity Read ↗

Exploiting the tumor phenotype using biodegradable submicron carriers of chemotherapeutic drugs.Semantic proximity Read ↗

Enhanced cytotoxicity and nuclear accumulation of doxorubicin-loaded nanospheres in human breast cancer MCF7 cells expressing MRP1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.