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Article

Understanding rhodopsin mutations linked to the retinitis pigmentosa disease: a QM/MM and DFT/MRCI study.

The journal of physical chemistry. B - 26 Jan 2012

Hernández-Rodríguez Erix Wiliam, Sánchez-García Elsa, Crespo-Otero Rachel, Montero-Alejo Ana Lilian, Montero Luis Alberto, Thiel Walter

Abstract excerpt

Retinitis pigmentosa (RP) is a pathological condition associated with blindness due to progressive retinal degeneration. RP-linked mutations lead to changes at the retinal binding pocket and in the absorption spectra. Here, we evaluate the geometries, electronic effects, and vertical excitation energies in the dark state of mutated human rhodopsins carrying the abnormal substitutions M207R or S186W at the retinal...

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PMID: 22126625
DOI: 10.1021/jp2037334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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