Nuclear Factor-κB Represses Hypoxia-Induced Mitochondrial Defects and Cell Death of Ventricular Myocytes

Abstract excerpt

BACKGROUND: Oxygen deprivation for prolonged periods of time provokes cardiac cell death and ventricular dysfunction. Preventing inappropriate cardiac cell death in patients with ischemic heart disease would be of significant therapeutic value as a means to improve ventricular performance. In the present study, we wished to ascertain whether activation of the cellular factor nuclear factor (NF)-kappaB suppresses...

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