Article
Genetic analysis of interleukin-1 receptor antagonist and interleukin-1β single-nucleotide polymorphisms C-511T and C+3953T in alopecia areata: susceptibility and severity association.
Clinical and experimental medicine - 1 May 2014
Alfadhli Suad, Nanda Arti
Abstract excerpt
The present study was aimed to explore the effect of two selected polymorphisms from interleukin-1β (IL-1β) gene [SNPs -511 and +3953] and a variable number of tandem repeat (VNTR) from interleukin-1 receptor antagonist (IL-1RN) on the susceptibility and severity of alopecia areata (AA) in Kuwaiti subjects. IL-1β SNPs C-511T, C+3953T, and IL-1RN VNTR were screened in 96 alopecia patients classified clinically,...
Topics
- Alopecia Areata
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Interleukin 1 Receptor Antagonist Protein
- Interleukin-1beta
- Kuwait
- Male
- Minisatellite Repeats
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Polymorphism, Single Nucleotide