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Article

Effects of glycosylation and pH conditions in the dynamics of human arylsulfatase A.

Journal of biomolecular structure & dynamics - 1 Apr 2014

Virgens Madza Yasodara Farias, Pol-Fachin Laercio, Verli Hugo, Saraiva-Pereira Maria Luiza

Abstract excerpt

Arylsulfatase A (ARSA) is a lysosomal sulfatase that catalyzes the hydrolysis of cerebroside sulfate. Its deficiency results in Metachromatic Leukodystrophy, whereas a minor condition called ARSA pseudodeficiency occurs in healthy individuals, which has been associated with the substitution of the glycosylated Asn350 by a Ser and with the loss of the polyadenylation signal. In this work, we have investigated ARSA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23581857
DOI: 10.1080/07391102.2013.780982

Genes

ARSA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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