Article
The lack of non-steroid isoprenoids causes oxidative stress in patients with mevalonic aciduria.
Medical hypotheses - 1 Jan 2008
Celec Peter, Behuliak Michal
Abstract excerpt
Mevalonic aciduria belongs to a group of rare inherited metabolic disorders related to cholesterol biosynthesis. The pathogenesis of mevalonic aciduria is not clear, although the cause is known - a genetic defect leading to a deficiency in mevalonate kinase activity. The lack of non-steroid isoprenoids in patients with mevalonic aciduria might cause oxidative stress due to a decreased production of endogenous...
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