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Article

Characterization of genetic lesions in rhabdomyosarcoma using a high-density single nucleotide polymorphism array.

Cancer science - 1 Jul 2013

Nishimura Riki, Takita Junko, Sato-Otsubo Aiko, Kato Motohiro, Koh Katsuyoshi, Hanada Ryoji, Tanaka Yukichi, Kato Keisuke, Maeda Daichi, Fukayama Masashi, Sanada Masashi, Hayashi Yasuhide, Ogawa Seishi

Abstract excerpt

Rhabdomyosarcoma (RMS) is a common solid tumor in childhood divided into two histological subtypes, embryonal (ERMS) and alveolar (ARMS). The ARMS subtype shows aggressive clinical behavior with poor prognosis, while the ERMS subtype has a more favorable outcome. Because of the rarity, diagnostic diversity and heterogeneity of this tumor, its etiology remains to be completely elucidated. Thus, to identify genetic...

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Identifiers

PMID: 23578105
DOI: 10.1111/cas.12173
PMCID: PMC7657110

Genes

ALK
IRS2
KRAS
NRAS

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