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Early B-Cell Differentiation in Merkel Cell Carcinomas: Clues to Cellular Ancestry

11 Apr 2013

Abstract excerpt

Merkel cell carcinoma (MCC) is a highly malignant neuroendocrine nonmelanoma skin cancer, which is associated with the Merkel cell polyoma virus (MCPyV). Recently, expression of the terminal deoxynucleotidyl transferase (TdT) and the paired box gene 5 (PAX 5) has been consistently reported in the majority of MCCs. We tested 21 MCCs for the expression of MCPyV, TdT, PAX5, IgG, IgM, IgA, kappa, and lambda by...

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PMID: 23576560
DOI: 10.1158/0008-5472.can-13-0616

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