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Article

Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43.

Human molecular genetics - 15 Sept 2009

Nonaka Takashi, Kametani Fuyuki, Arai Tetsuaki, Akiyama Haruhiko, Hasegawa Masato

Abstract excerpt

TAR DNA binding protein of 43 kDa (TDP-43) is a major component of the ubiquitin-positive inclusions found in the brain of patients with frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). Here, we report that expression of TDP-43 C-terminal fragments as green fluorescent protein (GFP) fusions in SH-SY5Y cells results in the formation of abnormally phosphorylated and ubiquitinated...

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Identifiers

PMID: 19515851
DOI: 10.1093/hmg/ddp275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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