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Article

Impact of ANKRD1 mutations associated with hypertrophic cardiomyopathy on contraction parameters of engineered heart tissue.

Basic research in cardiology - 1 May 2013

Crocini Claudia, Arimura Takuro, Reischmann Silke, Eder Alexandra, Braren Ingke, Hansen Arne, Eschenhagen Thomas, Kimura Akinori, Carrier Lucie

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is a myocardial disease associated with mutations in sarcomeric genes. Three mutations were found in ANKRD1, encoding ankyrin repeat domain 1 (ANKRD1), a transcriptional co-factor located in the sarcomere. In the present study, we investigated whether expression of HCM-associated ANKRD1 mutations affects contraction parameters after gene transfer in engineered heart tissues...

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Source

Identifiers

PMID: 23572067
DOI: 10.1007/s00395-013-0349-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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