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Dynamic changes in fetal Leydig cell populations influence adult Leydig cell populations in mice

8 Apr 2013

Abstract excerpt

Testes contain two distinct Leydig cell populations during development: fetal and adult Leydig cells (FLCs and ALCs, respectively). ALCs are not derived from FLCs, and it is unknown whether these two populations share common progenitors. We discovered that hedgehog (Hh) signaling is responsible for transforming steroidogenic factor 1-positive (SF1(+)) progenitors into FLCs. However, not all SF1(+) progenitors...

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PMID: 23568777
DOI: 10.1096/fj.12-225060

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