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Article

Fetal Leydig Cells: Progenitor Cell Maintenance and Differentiation

2 Jan 2010

Abstract excerpt

In most eutherian mammals, sexually dimorphic masculinization is established by androgen-producing fetal Leydig cells in the embryonic testis. Fetal Leydig cells, which lack expression of the testis-determining gene SRY, arise after the appearance of SRY-expressing Sertoli cells. Therefore, the appearance and differentiation of fetal Leydig cells are probably regulated by factors derived from Sertoli cells....

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Identifiers

PMID: 19875489
DOI: 10.2164/jandrol.109.008318

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