Article
TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors.
Cancer research - 1 Oct 2021
Maifrede Silvia, Le Bac Viet, Nieborowska-Skorska Margaret, Golovine Konstantin, Sullivan-Reed Katherine, Dunuwille Wangisa M B, Nacson Joseph, Hulse Michael, Keith Kelsey, Madzo Jozef, Caruso Lisa Beatrice, Gazze Zachary, Lian Zhaorui, Padella Antonella, Chitrala Kumaraswamy N, Bartholdy Boris A, Matlawska-Wasowska Ksenia, Di Marcantonio Daniela, Simonetti Giorgia, Greiner Georg, Sykes Stephen M, Valent Peter, Paietta Elisabeth M, Tallman Martin S, Fernandez Hugo F, Litzow Mark R, Minden Mark D, Huang Jian, Martinelli Giovanni, Vassiliou George S, Tempera Italo, Piwocka Katarzyna, Johnson Neil, Challen Grant A, Skorski Tomasz
Abstract excerpt
Somatic variants in TET2 and DNMT3A are founding mutations in hematological malignancies that affect the epigenetic regulation of DNA methylation. Mutations in both genes often co-occur with activating mutations in genes encoding oncogenic tyrosine kinases such as FLT3ITD, BCR-ABL1, JAK2V617F , and MPLW515L , or with mutations affecting related signaling pathways such as NRASG12D and CALRdel52 . Here, we show...
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