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Article

Impact of tryptophan metabolism on the vulnerability to alcohol-related blackouts and violent impulsive behaviours.

Alcohol and alcoholism (Oxford, Oxfordshire) - 1 Jan 2000

Vignau Jean, Soichot Marion, Imbenotte Michel, Jacquemont Marie-Claudine, Danel Thierry, Vandamme Michel, Lhermitte Michel, Allorge Delphine

Abstract excerpt

AIMS: We examined (1) the association of SLC6A4 genotypes and alcohol dependence (AD) in a sample of alcoholics; (2) the validity of lifetime occurrence of blacked-out violent impulsive behaviour (BOVIB) during binge drinking bouts as a criterion for subtyping AD patients and (3) a mechanistic hypothesis for BOVIB involving tryptophan-2,3-dioxygenase (TDO) activity. METHODS: Three common polymorphisms of the...

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Source

Identifiers

PMID: 19759277
DOI: 10.1093/alcalc/agp044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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