Article
Temporal analysis of hepatitis C virus cell entry with occludin directed blocking antibodies.
PLoS pathogens - 1 Mar 2013
Sourisseau Marion, Michta Maria L, Zony Chati, Israelow Benjamin, Hopcraft Sharon E, Narbus Christopher M, Parra Martín Ana, Evans Matthew J
Abstract excerpt
Hepatitis C virus (HCV) is a major cause of liver disease worldwide. A better understanding of its life cycle, including the process of host cell entry, is important for the development of HCV therapies and model systems. Based on the requirement for numerous host factors, including the two tight junction proteins claudin-1 (CLDN1) and occludin (OCLN), HCV cell entry has been proposed to be a multi-step process....
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