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Article

Monoclonal anti-claudin 1 antibodies prevent hepatitis C virus infection of primary human hepatocytes.

Gastroenterology - 1 Sept 2010

Fofana Isabel, Krieger Sophie E, Grunert Fritz, Glauben Sandra, Xiao Fei, Fafi-Kremer Samira, Soulier Eric, Royer Cathy, Thumann Christine, Mee Christopher J, McKeating Jane A, Dragic Tatjana, Pessaux Patrick, Stoll-Keller Francoise, Schuster Catherine, Thompson John, Baumert Thomas F

Abstract excerpt

BACKGROUND & AIMS: Hepatitis C virus (HCV) infection is a challenge to prevent and treat because of the rapid development of drug resistance and escape. Viral entry is required for initiation, spread, and maintenance of infection, making it an attractive target for antiviral strategies. The tight junction protein claudin-1 (CLDN1) has been shown to be required for entry of HCV into the cell. METHODS: Using...

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Source

Identifiers

PMID: 20685314
DOI: 10.1053/j.gastro.2010.05.073

Genes

CLDN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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