Article
Heat avoidance is regulated by transient receptor potential (TRP) channels and a neuropeptide signaling pathway in Caenorhabditis elegans.
Genetics - 1 May 2011
Glauser Dominique A, Chen Will C, Agin Rebecca, Macinnis Bronwyn L, Hellman Andrew B, Garrity Paul A, Tan Man-Wah, Goodman Miriam B
Abstract excerpt
The ability to avoid noxious extremes of hot and cold is critical for survival and depends on thermal nociception. The TRPV subset of transient receptor potential (TRP) channels is heat activated and proposed to be responsible for heat detection in vertebrates and fruit flies. To gain insight into the genetic and neural basis of thermal nociception, we developed assays that quantify noxious heat avoidance in the...
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