Article
A mutation in the mip gene results in an attenuation of Legionella pneumophila virulence.
The Journal of infectious diseases - 1 Jul 1990
Cianciotto N P, Eisenstein B I, Mody C H, Engleberg N C
Abstract excerpt
Infection by Legionella pneumophila is believed to depend upon its ability to multiply within host alveolar macrophages. To investigate this, a site-specific mutation was introduced into a gene (mip) that encodes a 24,000-Da surface protein; an 80-fold loss of infectivity for both U937 cells and...
Topics
- Animals
- Bacterial Proteins
- Cells, Cultured
- Disease Models, Animal
- Genes, Bacterial
- Guinea Pigs
- Legionella
- Legionnaires' Disease
- Lung
- Membrane Proteins
- Mutation
- Phagocytes