Article
Biochemical and functional analyses of the Mip protein: influence of the N-terminal half and of peptidylprolyl isomerase activity on the virulence of Legionella pneumophila.
Infection and immunity - 1 Aug 2003
Köhler Rolf, Fanghänel Jörg, König Bettina, Lüneberg Edeltraud, Frosch Matthias, Rahfeld Jens-Ulrich, Hilgenfeld Rolf, Fischer Gunter, Hacker Jörg, Steinert Michael
Abstract excerpt
The virulence factor Mip (macrophage infectivity potentiator) contributes to the intracellular survival of Legionella pneumophila, the causative agent of Legionnaires' disease. The protein consists of two domains that are connected via a very long alpha-helix (A. Riboldi-Tunnicliffe et al., Nat. Struct. Biol. 8:779-783, 2001). The fold of the C-terminal domain (residues 100 to 213) is closely related to human...
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