Article
Infectivity of Legionella pneumophila mip mutant for alveolar epithelial cells.
Current microbiology - 1 Apr 1995
Cianciotto N P, Stamos J K, Kamp D W
Abstract excerpt
Legionella pneumophila can invade and grow within explanted alveolar epithelial cells. Given its potential clinical significance, an examination of the molecular basis of epithelial cell infection was initiated. The mip gene encodes a 24-kilodalton surface protein that promotes macrophage infection and virulence. To determine whether this gene is required for pneumocyte infection, we tested a strain bearing a mip...
Topics
- Animals
- Cells, Cultured
- Epithelium
- Humans
- Legionella pneumophila
- Legionnaires' Disease
- Mutation
- Pulmonary Alveoli
- Rats
- Species Specificity