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Article

Circadian clock period inversely correlates with illness severity in cells from patients with alcohol use disorders.

Alcoholism, clinical and experimental research - 1 Aug 2013

McCarthy Michael J, Fernandes Malcolm, Kranzler Henry R, Covault Jonathan M, Welsh David K

Abstract excerpt

BACKGROUND: Clinical and genetic studies suggest circadian clock genes may contribute to biological mechanisms underlying alcohol use disorders (AUD). In particular, the Per2 gene regulates alcohol consumption in mutant animals, and in humans with AUD, the 10870 variant in PER2 has been associated with alcohol consumption. However, with respect to function, the molecular clock remains largely uncharacterized in...

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Source

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Identifiers

PMID: 23550834
DOI: 10.1111/acer.12106
PMCID: PMC3706548

Genes

PER2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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