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Article

Reduced Expression of Circadian Clock Genes in Male Alcoholic Patients

24 Aug 2010

Abstract excerpt

BACKGROUND: There are clear interactions between chronic alcohol consumption and circadian rhythmicity that is regulated by several circadian clock genes. The altered expressions of these genes have been mainly described in animals. The mammalian master clock in the suprachiasmatic nuclei orchestrates the biological rhythms in peripheral tissues. As peripheral blood mononuclear cells (PBMCs) are the most...

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PMID: 20735373
DOI: 10.1111/j.1530-0277.2010.01278.x

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