Bacterial protein- <i>O</i> -mannosylating enzyme is crucial for virulence of <i>Mycobacterium tuberculosis</i>

Abstract excerpt

A posttranslational protein O-mannosylation process resembling that found in fungi and animals has been reported in the major human pathogen Mycobacterium tuberculosis (Mtb) and related actinobacteria. However, the role and incidence of this process, which is essential in eukaryotes, have never been explored in Mtb. We thus analyzed the impact of interrupting O-mannosylation in the nonpathogenic saprophyte...

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