Article
Frequency of MDR1 single nucleotide polymorphisms in a Jordanian population, including a novel variant.
Genetics and molecular research : GMR - 13 Mar 2013
Khabour O F, Alzoubi K H, Al-Azzam S I, Mhaidat N M
Abstract excerpt
The multidrug resistance gene (MDR1 or ABCB1) codes for P-glycoprotein, which plays an important role in regulating absorption, distribution, and elimination of drugs. We examined MDR1 gene variants in 100 unrelated subjects from various regions of Jordan. The MDR1 gene was scanned using direct sequencing. Six rare variants in MDR1 were detected, including a new variant, T3075A. This variant did not affect the...
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