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Article

Establishment of HLA class I and MICA/B null HEK-293T panel expressing single MICA alleles to detect anti-MICA antibodies.

Scientific reports - 3 Aug 2021

Jeon Ji-Ho, Baek In-Cheol, Hong Cheol-Hwa, Park Ki Hyun, Lee Hyeyoung, Oh Eun-Jee, Kim Tai-Gyu

Abstract excerpt

Pre- and post-transplantation anti-MICA antibody detection development are associated with an increased rejection risk and low graft survival. We previously generated HLA class I null HEK-293T using CRISPR/Cas9, while MICA and MICB genes were removed in this study. A panel of 11 cell lines expressing single MICA alleles was established. Anti-MICA antibody in the sera of kidney transplant patients was determined...

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Identifiers

PMID: 34344955
DOI: 10.1038/s41598-021-95058-8
PMCID: PMC8333366

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