Dual role for Hox genes and Hox co-factors in conferring leg motoneuron survival and identity in Drosophila.

doi:10.1242/dev.090902

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Article

Dual role for Hox genes and Hox co-factors in conferring leg motoneuron survival and identity in Drosophila.

Development (Cambridge, England) - 1 May 2013

Baek Myungin, Enriquez Jonathan, Mann Richard S

Abstract excerpt

Adult Drosophila walk using six multi-jointed legs, each controlled by ∼50 leg motoneurons (MNs). Although MNs have stereotyped morphologies, little is known about how they are specified. Here, we describe the function of Hox genes and homothorax (hth), which encodes a Hox co-factor, in Drosophila leg MN development. Removing either Hox or Hth function from a single neuroblast (NB) lineage results in MN...

Topics

Animals
Antennapedia Homeodomain Protein
Apoptosis
Axons
Cell Lineage
Cell Survival
Dendritic Cells
Drosophila Proteins
Drosophila melanogaster
Embryo, Nonmammalian
Extremities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Developmental

Genes, Insect

Homeodomain Proteins

Immunohistochemistry

Mitosis

Motor Neurons

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 23536569
DOI: 10.1242/dev.090902
PMCID: PMC3631975

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23536569-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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