Article
The Caenorhabditis elegans gene ham-2 links Hox patterning to migration of the HSN motor neuron.
Genes & development - 15 Feb 1999
Baum P D, Guenther C, Frank C A, Pham B V, Garriga G
Abstract excerpt
The Caenorhabditis elegans HSN motor neurons permit genetic analysis of neuronal development at single-cell resolution. The egl-5 Hox gene, which patterns the posterior of the embryo, is required for both early (embryonic) and late (larval) development of the HSN. Here we show that ham-2 encodes a zinc finger protein that acts downstream of egl-5 to direct HSN cell migration, an early differentiation event. We...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Differentiation
- Cell Movement
- Cloning, Molecular
- Gene Expression Regulation, Developmental
- Genes, Homeobox
- Helminth Proteins
- Homeodomain Proteins
- Microscopy, Fluorescence