[Application and value of mutation detection in diagnosis and treatment of gastrointestinal stromal tumor].

Abstract excerpt

Mutation of c-kit and platelet-derived growth factor receptor alpha (PDGFRA) is the most important molecular feature of gastrointestinal stromal tumor (GIST). Mutation detection of these two genes is of great significance when establishing the diagnosis of a kit-negative GIST, or when predicting response to tyrosine kinase inhibitor. Furthermore, more and more researches focus on the feasibility of the mutation...

Topics

• Gastrointestinal Neoplasms
• Gastrointestinal Stromal Tumors
• Humans
• Mutation
• Proto-Oncogene Proteins c-kit
• Receptor, Platelet-Derived Growth Factor alpha