[Molecular mechanism of gastrointestinal stromal tumors and progress in drug research].

Abstract excerpt

The functional mutation of c-kit and platelet-derived growth factor receptor α (PDGFRA) which encode proto-oncogene receptor tyrosine kinase are the crucial pathogeneses of gastrointestinal stromal tumors(GISTs). 80%-85% c-kit gene mutation including exon 11,exon 9,exon 13,exon 17 and 5%-10% PDGFRA gene mutation such as exon 18, exon 12 are examined in GISTs. Neither of c-kit or PDGFRA gene mutation are called...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Benzimidazoles
• Share to Gastrointestinal Stromal Tumors
• Share to Imatinib Mesylate