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Article

Structural and functional characterization of the Clostridium perfringens N-acetylmannosamine-6-phosphate 2-epimerase essential for the sialic acid salvage pathway.

The Journal of biological chemistry - 19 Dec 2014

Pélissier Marie-Cécile, Sebban-Kreuzer Corinne, Guerlesquin Françoise, Brannigan James A, Bourne Yves, Vincent Florence

Abstract excerpt

Pathogenic bacteria are endowed with an arsenal of specialized enzymes to convert nutrient compounds from their cell hosts. The essential N-acetylmannosamine-6-phosphate 2-epimerase (NanE) belongs to a convergent glycolytic pathway for utilization of the three amino sugars, GlcNAc, ManNAc, and sialic acid. The crystal structure of ligand-free NanE from Clostridium perfringens reveals a modified triose-phosphate...

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Identifiers

PMID: 25320079
DOI: 10.1074/jbc.M114.604272
PMCID: PMC4271210

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