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Article

An in vivo drug screening model using glucose-6-phosphate dehydrogenase deficient mice to predict the hemolytic toxicity of 8-aminoquinolines.

The American journal of tropical medicine and hygiene - 1 Jun 2013

Zhang Peng, Gao Xiugong, Ishida Hiroshi, Amnuaysirikul Jack, Weina Peter J, Grogl Max, O'Neil Michael T, Li Qigui, Caridha Diana, Ohrt Colin, Hickman Mark, Magill Alan J, Ray Prabhati

Abstract excerpt

Anti-malarial 8-aminoquinolines drugs cause acute hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase deficiency (G6PDD). Efforts to develop non-hemolytic 8-aminoquinolines have been severely limited caused by the lack of a predictive in vivo animal model of hemolytic potential that would allow screening of candidate compounds. This report describes a G6PDD mouse model with a phenotype closely...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23530079
DOI: 10.4269/ajtmh.12-0682
PMCID: PMC3752814

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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