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Mirk/dyrk1B Kinase in Ovarian Cancer

8 Mar 2013

Abstract excerpt

Mirk/dyrk1B kinase is expressed in about 75% of resected human ovarian cancers and in most ovarian cancer cell lines with amplification in the OVCAR3 line. Mirk (minibrain-related kinase) is a member of the Minibrain/dyrk family of related serine/threonine kinases. Mirk maintains cells in a quiescent state by stabilizing the CDK inhibitor p27 and by inducing the breakdown of cyclin D isoforms. Mirk also...

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PMID: 23528858
DOI: 10.3390/ijms14035560

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