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Article

Alanine-metabolizing enzyme Alt1 is critical in determining yeast life span, as revealed by combined metabolomic and genetic studies.

Journal of proteome research - 5 Apr 2013

Yu Sung-Lim, An Yong Jin, Yang Hey-Ji, Kang Mi-Sun, Kim Ho-Yeol, Wen He, Jin Xing, Kwon Hyuk Nam, Min Kyung-Jin, Lee Sung-Keun, Park Sunghyouk

Abstract excerpt

Alterations in metabolic pathways are gaining attention as important environmental factors affecting life span, but the determination of specific metabolic pathways and enzymes involved in life span remains largely unexplored. By applying an NMR-based metabolomics approach to a calorie-restricted yeast (Saccharomyces cerevisiae) model, we found that alanine level is inversely correlated with yeast chronological...

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PMID: 23527786
DOI: 10.1021/pr300979r

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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